A virtual disease gene cloning project - from pathology to protein structure and function

Description

A 'virtual positional cloning experiment' using a problem-based learning approach and delivered via a WWW-interface this project aims to enable students to establish the connection between disease pathology and altered molecular cellular components leading to the disease state. It uses a stepwise approach by accessing a number of molecular databases and retrieving information on genomic regions, candidate genes and proteins, gene mutations and resulting protein structure/function alterations.

Outcomes and downloads

• Genome website: http://dea.brunel.ac.uk/GATC

Links

• A series of interactive virtual lectures in genes and chromosomes